Dose-Response Relationship (16 points) You were hired by a pharmaceutical company to study a new blood thinner. To understand dose-response relationship of this medicine, you conducted an experiment in rabbits. You decided to generate a blood clot in rabbit’s ears and see if the injection of this blood thinner into the blood can help dissolve the clot. So, the left ear of rabbits were injected with coagulant and blood clots were formed. Two hours later, all rabbits were injected with this blood thinner and responses were recorded.
Table 1 recorded effective doses and # of response to the blood thinner. However, rabbits began to suffer hemorrhage (bleeding) with the exposure dose equal or higher than 40 mg/kg.
Table 2 recorded lethal/toxic doses and # of response to the blood thinner.
Would you suggest your company to sell this blood thinner? You need to complete the following to get the answer:
(1) Complete cumulative % response calculations (4 pts)
(2) plot a % cumulative-response curve for effective response, and a % cumulative-response curve for lethal/toxic response on the same graph. (3×2 = 6 pts)
(3) Answer the questions after you plot the curves. (3×1 + 3 = 6 pts)
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