Prominent journal on the topic of osteoporosis

Imagine that you have been asked to write a scientific article to be published in a prominent journal on the topic of osteoporosis as a multifactorial disease. Prepare a written paper of at least 1000 words on the following bullet points:
What is the functional relationship between the integumentary and skeletal systems?
How does failure to maintain homeostasis in the integumentary system affect bone formation and remodeling processes? Be sure to discuss how the different types of bone cells respond to different factors (e.g., ions, hormones, cellular signaling molecules, etc.) and what the driving force behind maintaining homeostasis in the bone remodeling process.
Describe the pathogenesis of osteoporosis and explain why it is considered a multifactorial disease.
How do current therapies address these failures to maintain homeostasis and ameliorate the effects of osteoporosis?
Your paper should be formatted as a proper research paper with an introduction and conclusion. Do not simply follow the bullet points above, but really think about what you have learned and how that relates to other material we have covered, and knowledge you have from other courses you may have taken. The Research and Report assignments in this course are capstone assignments for each module. You should be integrating everything that you learned in the textbook, explorations, discussions, and lab activities into your papers.